R-Rsolid-0.9.31-46.fc40 $L>$< 6 6_"6 3!]W>D] 'p~[ye 'p~[ỷ\|P uv# ;R3 aW.N ݭ}X!.uٍv}uZ% tގ>|ڄ?׾#K)欂Rʓ iק:qO=U74Ѥ>3I_k2 #K7Y'@^W. ùU+I,鿱 L-M>Y=#@-r^HFtr H=RD] 'p~[ye 'p~[ybkj0QwEE`@ ):j rd> wuUXAku KFWm젚?V/1t(`ߗbw_mjcduj AKbVhQ?QnMBHUEN}FKT{or]^@~1wk(dL D!u`O4ف66vΌ2zgPnw\cj;͘=u)h+5g/`Pi?Z`%S.9cn1oK ?/oSŝf` @;"* .\f 1Ri;#Qp^jܡV\-Tպ3^,m5ek%) bӜf:!,Xqd;Bұeݼg0H(-E ciaS+یEb`\.f1E/M킺%b -1j>`>?d   h $LP_n{ "P" " " `"  "  "d"""`   ( 894:G"H4"I"XY\"]"^ bdeflt"u"vw"xX"y  4:|CR-Rsolid0.9.3146.fc40Quantile normalization and base calling for second generation sequencing data Rsolid is an R package for normalizing fluorescent intensity data from ABI/SOLiD second generation sequencing platform. It has been observed that the color-calls provided by factory software contain technical artifacts, where the proportions of colors called are extremely variable across sequencing cycles. Under the random DNA fragmentation assumption, these proportions should be equal across sequencing cycles and proportional to the dinucleotide frequencies of the sample. Rsolid implements a version of the quantile normalization algorithm that transforms the intensity values before calling colors. Results show that after normalization, the total number of mappable reads increases by around 5%, and number of perfectly mapped reads increases by 10%. Moreover a 2-5% reduction in overall error rates is observed, with a 2-6% reduction in the rate of valid adjacent color mis-matches. The latter is important, since it leads to a decrease in false-positive SNP calls. The normalization algorithm is computationally efficient. In a test we are able to process 300 million reads in 2 hours using 10 computer cluster nodes. The engine functions of the package are written in C for better performance.eފbuildvm-a64-08.iad2.fedoraproject.org7Fedora ProjectFedora ProjectArtistic 2.0Fedora ProjectUnspecifiedhttp://rafalab.jhsph.edu/Rsolid/linuxaarch6457[~7vz"9La `t4 AAA큤A큤A큤A큤A큤A큤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../../../../usr/lib64/R/library/Rsolid/libs/Rsolid.sorootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootrootR-Rsolid-0.9.31-46.fc40.src.rpmR(Rsolid)R-RsolidR-Rsolid(aarch-64)@@@@@@@@    @R(ABI)R-coreld-linux-aarch64.so.1()(64bit)ld-linux-aarch64.so.1(GLIBC_2.17)(64bit)libR.so()(64bit)libc.so.6()(64bit)libc.so.6(GLIBC_2.17)(64bit)libhdf5.so.200()(64bit)rpmlib(CompressedFileNames)rpmlib(FileDigests)rpmlib(PayloadFilesHavePrefix)rpmlib(PayloadIsZstd)rtld(GNU_HASH)4.33.0.4-14.6.0-14.0-15.4.18-14.19.1eXed@d@dI@dBzc@cAb@Fedora Release Engineering - 0.9.31-46Fedora Release Engineering - 0.9.31-45Fedora Release Engineering - 0.9.31-44Florian Weimer - 0.9.31-43Iñaki Úcar - 0.9.31-42Fedora Release Engineering - 0.9.31-41Iñaki Úcar - 0.9.31-40Fedora Release Engineering - 0.9.31-39- Rebuilt for https://fedoraproject.org/wiki/Fedora_40_Mass_Rebuild- Rebuilt for https://fedoraproject.org/wiki/Fedora_40_Mass_Rebuild- Rebuilt for https://fedoraproject.org/wiki/Fedora_39_Mass_Rebuild- Port configure script to c99- R-maint-sig mass rebuild- Rebuilt for https://fedoraproject.org/wiki/Fedora_38_Mass_Rebuild- R 4.2.1- Rebuilt for https://fedoraproject.org/wiki/Fedora_37_Mass_Rebuild  !"0.9.310.9.31-46.fc400.9.31-46.fc40  .build-idf2eb73c8311199d6b2c71b3c52fbf8dc9ff934bbRsolidDESCRIPTIONINDEXMetaRd.rdsdata.rdsfeatures.rdshsearch.rdslinks.rdsnsInfo.rdspackage.rdsNAMESPACERRsolidRsolid.rdbRsolid.rdxdataprop.Hs.rdahelpAnIndexRsolid.htmlRsolid.rdbRsolid.rdxaliases.rdspaths.rdshtml00Index.htmlR.cssRsolid.htmllibsRsolid.so/usr/lib//usr/lib/.build-id//usr/lib/.build-id/f2//usr/lib64/R/library//usr/lib64/R/library/Rsolid//usr/lib64/R/library/Rsolid/Meta//usr/lib64/R/library/Rsolid/R//usr/lib64/R/library/Rsolid/data//usr/lib64/R/library/Rsolid/help//usr/lib64/R/library/Rsolid/html//usr/lib64/R/library/Rsolid/libs/-O2 -flto=auto -ffat-lto-objects -fexceptions -g -grecord-gcc-switches -pipe -Wall -Wno-complain-wrong-lang -Werror=format-security -Wp,-U_FORTIFY_SOURCE,-D_FORTIFY_SOURCE=3 -Wp,-D_GLIBCXX_ASSERTIONS -specs=/usr/lib/rpm/redhat/redhat-hardened-cc1 -fstack-protector-strong -specs=/usr/lib/rpm/redhat/redhat-annobin-cc1 -mbranch-protection=standard -fasynchronous-unwind-tables -fstack-clash-protection -fno-omit-frame-pointer -mno-omit-leaf-frame-pointercpiozstd19aarch64-redhat-linux-gnudirectoryASCII textHTML documentELF 64-bit LSB shared object, ARM aarch64, version 1 (SYSV), dynamically linked, BuildID[sha1]=f2eb73c8311199d6b2c71b3c52fbf8dc9ff934bb, strippedPRRRRRRRRR https://bugz.fedoraproject.org/R-Rsolidutf-81bb358309f2268048722d0712cd6015f8d9331a38ca3b1d634d4f0b3ee466d0a278fc0385a01d591a6ec63616dcf25a6463f4cada203aaa5ccbbab56116ce904? (/hl3071041ed165adb014./usr/lib/.build-id27/f23a1ff353e/eb73c8311199d6b2c71b3c52fbf8dc9ff934bb../64/Rrary/Rsols.so4d581a428d29/DESCRIPTIONPackage: Version: 0.9-31 Dat2-08-04 TitlQuantile normalizat and color calling fsecogener quencdata from ABI SOLiD platf Author: Hao Wu, HectCorrada BravoRafael Irriz Mainte Depends: Suggests:scriptImplements procedure dbed in H.,ry R. A.ntensityimves. NatMeds, 7, 336-337. 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